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Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight.

Journal article
Authors Jessica Bah Rösman
Lars Westberg
Fariba Baghaei
Susanne Henningsson
Roland Rosmond
Jonas Melke
Göran Holm
Elias Eriksson
Published in Metabolism
Volume 59
Issue 8
Pages 1156-1163
ISSN 0026-0495
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1156-1163
Language en
Keywords Polymorphisms, HTR2C, 5HTT, body weight
Subject categories Pharmacology and Toxicology


Receptors of the 5-HT2C subtype are of importance for the influence of serotonin on food intake, and 2 single nucleotide polymorphisms in this gene (HTR2C)-Cys23Ser (rs6318) and -759C>T (rs3813929)-have been reported to be associated with weight and/or antipsychotic-induced weight gain. The present study aimed to replicate these associations; in addition, the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) was assessed. The polymorphisms were genotyped in subjects recruited from the normal population (n = 510), and possible associations between genotype and body mass index (BMI) were assessed. The Ser23 allele was more common in underweight subjects (BMI <20) than in normal- and overweight (BMI >/=20) subjects (P = .006). The T allele of the -759C/T polymorphism was less common in the overweight group (BMI >/=25) (P = .007). Homozygosity for the short allele of 5-HTTLPR was more frequent in underweight subjects (P = .015). Our results are in agreement with previous studies, suggesting polymorphisms in HTR2C to be associated with body weight, particularly in women; and they also suggest that 5-HTTLPR may influence this phenotype. Further studies on the importance of the investigated genes for eating disorders and drug-induced weight gain are warranted.

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