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Premixed acidic calcium phosphate cement: Characterization of strength and microstructure.

Journal article
Authors Jonas Åberg
Helena Brisby
Helena Barreto Henriksson
Anders Lindahl
Peter Thomsen
Håkan Engqvist
Published in Journal of biomaterials research. Part B. Applied biomaterials
Volume 93
Issue 2
Pages 436-41
ISSN 1552-4981
Publication year 2010
Published at Institute of Biomedicine
Institute of Clinical Sciences, Department of Biomaterials
Institute of Clinical Sciences, Department of Orthopaedics
Pages 436-41
Language en
Subject categories Biomaterials Science, Clinical Medicine


By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste. As the paste does not contain water, no setting reaction starts and thus the working time is indefinite. Powder/liquid ratios (P/L) of 2.25, 3.5 and 4.75 were evaluated. Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction. The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST. Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa. The microstructure mainly consisted of monetite, 1-5 mum in grain size. After 4 weeks in PBS, the strength increased. As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements. Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010.

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