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Levodopa responsiveness in disorders with parkinsonism: a review of the literature.

Journal article
Authors Radu Constantinescu
Irene Richard
Roger Kurlan
Published in Movement disorders : official journal of the Movement Disorder Society
Volume 22
Issue 15
Pages 2141-8; quiz 2295
ISSN 0885-3185
Publication year 2007
Published at
Pages 2141-8; quiz 2295
Language en
Keywords Antiparkinson Agents, therapeutic use, Education, Medical, Continuing, Humans, Levodopa, therapeutic use, Parkinsonian Disorders, drug therapy
Subject categories Medical and Health Sciences


A literature review was conducted to investigate whether or not levodopa (LD) responsiveness (LR) is a useful criterion in the diagnosis of parkinsonian disorders. Although LR does appear to differ among the parkinsonian disorders, there is considerable confusion in the literature. While most patients with Parkinson's disease (PD) have a sustained benefit from LD, a small minority of patients with documented PD do not respond. The literature suggests that the LR rate is higher for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) than based on published diagnostic criteria. Magnitude and duration of response to LD and tolerability (time course, type and distribution of dyskinesias, mental effects and motor worsening) may be useful features in distinguishing PD, MSA, PSP, and CBD. Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications.

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