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Progress in vaccine development against Helicobacter pylori.

Review article
Authors Ann-Mari Svennerholm
Anna Lundgren
Published in FEMS immunology and medical microbiology
Volume 50
Issue 2
Pages 146-56
ISSN 0928-8244
Publication year 2007
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 146-56
Language en
Keywords Antigens, Bacterial, genetics, immunology, Bacterial Vaccines, genetics, immunology, Helicobacter Infections, immunology, prevention & control, Helicobacter pylori, immunology, Humans
Subject categories Microbiology in the medical area


Based on the very high prevalence of diseases caused by Helicobacter pylori, particularly in the developing world, and the rapid emergence of antibiotic resistance among clinical isolates, there is a strong rationale for an effective vaccine against H. pylori. In this review we describe recent promising candidate vaccines and prophylactic or therapeutic immunization strategies for use against H. pylori, as well as studies to identify immune responses that are related to protection in experimental animals. We also describe identification of different types of immune responses that may be related to protection against symptoms based on comparisons of H. pylori-infected patients with duodenal ulcers or gastric cancer and asymptomatic carriers. We conclude that there is still a strong need to clarify the main protective immune mechanisms against H. pylori as well as to identify a cocktail of strong protective antigens, or recombinant bacterial strains that express such antigens, that could be administered by a regimen that gives rise to effective immune responses in humans.

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