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Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial.

Journal article
Authors Suman Kanungo
Allison Paisley
Anna Lena Lopez
Mihir Bhattacharya
Byomkesh Manna
Deok Ryun Kim
Seung Hyun Han
Stephen Attridge
Rodney Carbis
Raman Rao
Jan Holmgren
John D Clemens
Dipika Sur
Published in Vaccine
Volume 27
Issue 49
Pages 6887-93
ISSN 1873-2518
Publication year 2009
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 6887-93
Language en
Links dx.doi.org/10.1016/j.vaccine.2009.0...
Keywords Administration, Oral, Adolescent, Adult, Antibodies, Bacterial, blood, Antibody Formation, Child, Child, Preschool, Cholera, immunology, prevention & control, Cholera Vaccines, immunology, Double-Blind Method, Female, Humans, Immunization, Secondary, India, Infant, Male, Vaccines, Inactivated, immunology, Young Adult
Subject categories Microbiology in the medical area

Abstract

Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in Kolkata, India. 65% of adults and 87% of children and 46% of adults and 82% of children exhibited a > or =4-fold rise in serum Vibrio cholerae O1 vibriocidal antibody titers from baseline following dose 1 and 2, respectively. Responses to V. cholerae O139 were less pronounced but followed a similar pattern. We demonstrate that in a cholera-endemic area, the vaccine elicited vibriocidal responses after a single-dose of the vaccine.

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