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Endodontic variables and coronary heart disease.

Journal article
Authors Fredrik Frisk
Magnus Hakeberg
Margareta Ahlqwist
Calle Bengtsson
Published in Acta odontologica Scandinavica
Volume 61
Issue 5
Pages 257-62
ISSN 0001-6357
Publication year 2003
Published at Institute of Odontology
Institute of Community Medicine, Dept of Primary Health Care
Pages 257-62
Language en
Keywords Adult, Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, epidemiology, Angina Pectoris, epidemiology, Body Constitution, Body Mass Index, Cholesterol, blood, Coronary Disease, epidemiology, Cross-Sectional Studies, Dental Pulp Diseases, epidemiology, Female, Humans, Logistic Models, Middle Aged, Myocardial Infarction, epidemiology, Periapical Diseases, epidemiology, Risk Factors, Root Canal Therapy, statistics & numerical data, Smoking, epidemiology, Sweden, epidemiology, Tooth Loss, epidemiology, Triglycerides, blood
Subject categories Odontological behavioural science


This cross-sectional study was designed to explore a possible association between endodontic disease variables and coronary heart disease (CHD). Dental infections are hypothesized to be linked to atherosclerosis and could be a cause of vascular changes crucial for the development of CHD. Most studies have focused on periodontal disease. To our knowledge, no one has specifically studied endodontic variables as risk factors for the development of CHD. In 1992-93, a representative sample (n = 1056) of women in Göteborg, Sweden, aged between 38 and 84 years, took part in a combined dental and medical survey. The dependent variable was CHD, i.e. subjects with angina pectoris and/or a history of myocardial infarction (n = 106). The independent variables were number of root-filled teeth (RF), number of teeth with periapical radiolucencies (PA), tooth loss (TL), age, life situation, marital status, smoking, alcohol habits, body mass index, waist-hip ratio, serum cholesterol and triglyceride concentrations, hypertension and diabetes. The multivariate logistic regression analysis did not prove the endodontic variables to be predictive of CHD. Only age and tooth loss were significantly associated with CHD, with OR = 1.07 (CI = 1.03-1.12) and OR = 2.70 (CI = 1.49-4.87), respectively. The bivariate logistic regression analysis showed a positive significant association between subjects with RF = 2 and CHD, but for PA the bivariate analysis did not support an association with CHD. This cross-sectional study did not reveal a significant association between endodontically treated teeth and CHD nor between teeth with periapical disease and CHD.

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