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CSF biomarkers: pinpointing Alzheimer pathogenesis.

Review article
Authors Niklas Mattsson
Kaj Blennow
Henrik Zetterberg
Published in Annals of the New York Academy of Sciences
Volume 1180
Pages 28-35
ISSN 1749-6632
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 28-35
Language en
Links dx.doi.org/10.1111/j.1749-6632.2009...
Keywords Alzheimer Disease, cerebrospinal fluid, etiology, pathology, Biological Markers, cerebrospinal fluid, Clinical Trials as Topic, Humans, Inflammation, pathology, Synapses, pathology
Subject categories Neurochemistry

Abstract

Intense research during the last decades has resulted in an unprecedented accumulation of knowledge regarding the pathogenesis of Alzheimer's disease. Primarily, the focus has been directed toward amyloid and tau pathology and their relations to synaptic and neuronal loss. However, as the complexity of the disease becomes increasingly evident, the importance of other factors, such as inflammation, oxidative stress, and mitochondrial dysfunction, grow apparent. Here, we review available CSF biomarkers for these pathological processes. We also consider their usability in clinical practice and in clinical trials.

Page Manager: Webmaster|Last update: 9/11/2012
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