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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.

Journal article
Authors Bob Olsson
Per-Ola Andersson
Margareta Jernås
Stefan Jacobsson
Björn Carlsson
Lena M S Carlsson
Hans Wadenvik
Published in Nature medicine
Volume 9
Issue 9
Pages 1123-4
ISSN 1078-8956
Publication year 2003
Published at Institute of Internal Medicine, Dept of Medicine
Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
Pages 1123-4
Language en
Links dx.doi.org/10.1038/nm921
Keywords Blood Platelets, immunology, physiology, Case-Control Studies, Cytotoxicity, Immunologic, genetics, Granzymes, Humans, Interferon-gamma, genetics, Membrane Glycoproteins, genetics, Oligonucleotide Array Sequence Analysis, Perforin, Pore Forming Cytotoxic Proteins, Purpura, Thrombocytopenic, Idiopathic, blood, genetics, immunology, Receptors, Immunologic, genetics, Receptors, Interleukin-2, genetics, Receptors, KIR, Serine Endopeptidases, genetics, T-Lymphocytes, Cytotoxic, immunology, physiology
Subject categories Molecular medicine, Hematology

Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

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