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Effect of hypocalcemic state on enamel formation in rat maxillary incisors.

Journal article
Authors L Ranggård
Jörgen G Norén
Published in Scandinavian journal of dental research
Volume 102
Issue 5
Pages 249-53
ISSN 0029-845X
Publication year 1994
Published at Institute of Odontology, Department of Pedodontics
Pages 249-53
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Ameloblasts, cytology, Amelogenesis, physiology, Animals, Calcium, blood, deficiency, Dental Enamel, anatomy & histology, chemistry, Dental Enamel Hypoplasia, etiology, pathology, physiopathology, Dentin, anatomy & histology, Hypocalcemia, blood, physiopathology, Incisor, anatomy & histology, Male, Maxilla, Minerals, chemistry, Osteogenesis, physiology, Rats, Rats, Sprague-Dawley, Skull, anatomy & histology, growth & development, Tooth Calcification, physiology, Vitamin D Deficiency, physiopathology, Weight Gain
Subject categories Paedodontics

Abstract

Several authors have proposed that hypocalcemia can interfere with amelogenesis, resulting in enamel aberrations. Therefore, the purpose of this investigation was to study the effects of a diet-induced hypocalcemic state in young rats on enamel formation of the maxillary incisors. The experimental rats were fed a special diet, free from vitamin D and very low in calcium. The control rats were fed a normal diet. The experimental period was 3 wk. After termination, the blood analysis showed that the experimental rats had developed hypocalcemia with very low values of both total and ionized blood calcium. The experimental rats were smaller than their controls after 3 wk, with smaller skulls and teeth. At the light microscope level, the enamel and the ameloblasts did not seem to be affected, except in one rat, the smallest, which showed enamel hypoplasias in both maxillary incisors and a delayed increase of the mineral content during the maturation stage process. It is concluded that the hypocalcemic state induced did not greatly affect enamel formation. However, occasional enamel aberrations may occur.

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