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Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients

Journal article
Authors Aylin Yilmaz
V Watson
L Else
Magnus Gisslén
Published in AIDS
Volume 23
Issue 18
Pages 2537-2540
ISSN 0269-9370
Publication year 2009
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 2537-2540
Language en
Links dx.doi.org/10.1097/QAD.0b013e328333...
Subject categories Microbiology in the medical area

Abstract

In order to assess the penetration of maraviroc to the central nervous system, we measured maraviroc concentrations in cerebrospinal fluid (CSF) and plasma. Concentrations were determined by liquid chromatography tandem mass spectrometry (lower limit of quantitation 1.25 ng/ml) in seven paired CSF and plasma samples. The median plasma maraviroc concentration was 94.9 ng/ml (range 21.4-478.0) and the median CSF concentration was 3.63 ng/ml (range 1.83-12.2). CSF samples exceeded the median EC90 for maraviroc (0.57 ng/ml) by at least three-fold. The CSF levels of maraviroc found in this study likely contribute to viral suppression in the CSF.

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