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Structure casts light on mtDNA replication.

Magazine article
Authors Maria Falkenberg
Nils-Göran Larsson
Published in Cell
Volume 139
Issue 2
Pages 231-3
ISSN 1097-4172
Publication year 2009
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 231-3
Language en
Links dx.doi.org/10.1016/j.cell.2009.09.0...
Subject categories Chemistry

Abstract

In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.

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