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CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment.

Journal article
Authors Clas Malmeström
Markus Axelsson
Jan Lycke
Henrik Zetterberg
Kaj Blennow
Bob Olsson
Published in Journal of neuroimmunology
Volume 269
Issue 1-2
Pages 87-9
ISSN 1872-8421
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 87-9
Language en
Subject categories Neurochemistry


The role of glial cells during different phases of multiple sclerosis (MS) is unclear. To monitor glial activation we analyzed the biomarkers YKL-40 and sCD14 in cerebrospinal fluid (CSF) from MS patients during different disease phases and in response to immunosuppressive treatment. CSF levels of YKL-40 were increased in MS during relapse, remission and secondary progression compared with healthy controls. Furthermore, YKL-40 levels in CSF decreased by mitoxantrone and natalizumab treatment. No differences were observed in CSF levels of sCD14. Thus, we can infer that glial activation is present in all MS phases and decreases by immunosuppressive treatment.

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