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| Authors |
Gerdt C. Riise Gunnar Mårtensson Birgitta Houltz Björn Bake |
|---|---|
| Published in | BMC research notes |
| Volume | 4 |
| Issue | 1 |
| Pages | 515 |
| ISSN | 1756-0500 |
| Publication year | 2011 |
| Published at |
Institute of Medicine, Department of Internal Medicine |
| Pages | 515 |
| Language | en |
| Links |
dx.doi.org/10.1186/1756-0500-4-515 https://gup.ub.gu.se/file/105390 |
| Subject categories | Medical and Health Sciences |
BACKGROUND: The present study analyses the ability of the alveolar slope of the single-breath nitrogen washout test (N2-slope) to diagnose and predict the development of the bronchiolitis obliterans syndrome (BOS). METHODS: We present a retrospective analysis of 61 consecutive bilateral lung or heart-lung transplant recipients who were followed at regular control visits during a three year follow-up. The operating characteristics of the N2-slope to diagnose BOS and potential BOS (BOS 0-p) and to predict BOS were determined based on cut off values of 95% specificity. RESULTS: The sensitivity of the N2-slope to identify BOS was 96%, and BOS 0-p 100%. The predictive ability to predict BOS with a N2-slope > 478% of the predicted normal was 56%, and if combined with a coincident FEV1 < 90% of the basal value, the predictive ability was 75%. CONCLUSIONS: The predictive ability of either the N2-slope or of FEV1 to diagnose BOS is limited but the combination of the two appears useful. Follow-up protocols of bilateral lung and heart-lung transplant recipients should consider including tests sensitive to obstruction of the peripheral airways.
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