To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A 10-Year Follow-Up of Ad… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and Older

Journal article
Authors I. A. C. Arnoldussen
Valter Sundh
Kristoffer Bäckman
Silke Kern
Svante Östling
Kaj Blennow
Henrik Zetterberg
Ingmar Skoog
Amanda Kiliaan
Deborah Gustafson
Published in Journal of Alzheimers Disease
Volume 63
Issue 4
Pages 1325-1335
ISSN 1387-2877
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Centre for Ageing and Health (Agecap)
Pages 1325-1335
Language en
Keywords Adiponectin, body mass index, dementia, elderly, leptin, waist hip ratio, body-mass index, mild cognitive impairment, plasma leptin levels, alzheimer-disease, frontotemporal dementia, cardiovascular risk, weight-loss, brain, population, obesity, Neurosciences & Neurology
Subject categories Neurochemistry, Neurology


Background: Adiposity measured in mid-or late-life and estimated using anthropometric measures such as body mass index (BMI) and waist-to-hip ratio (WHR), or metabolic markers such as blood leptin and adiponectin levels, is associated with late-onset dementia risk. However, during later life, this association may reverse and aging- and dementia-related processes may differentially affect adiposity measures. Objective: We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence. Methods: 924 Swedish community-dwelling elderly without dementia, aged 70 years and older, systematically-sampled by birth day and birth year population-based in the Gothenburg city region of Sweden. The Gothenburg Birth Cohort Studies are designed for evaluating risk and protective factors for dementia. All dementias diagnosed after age 70 for 10 years were identified. Multivariable logistic regression models were used to predict dementia occurrence between 2000-2005, 2005-2010, and 2000-2010 after excluding prevalent baseline (year 2000) dementias. Baseline levels of BMI, WHR, leptin, and adiponectin were used. Results: Within 5 years of baseline, low BMI (<20 kg/m(2)) was associated with higher odds of dementia compared to those in the healthy BMI category (>= 20-24.9 kg/m(2)). Compared to the lowest quartile, leptin levels in the second quartile were associated with lower odds of dementia in women (p < 0.05). Conclusion: In late-life, anthropometric and metabolic adiposity measures appear to be differentially associated with dementia risk. While BMI and leptin levels are highly positively correlated, our results show that their association with dementia at age >= 70 years, is asynchronous. These data suggest that with aging, the complexity of the adiposity exposure may increase and suggests metabolic dysregulation. Additional studies are needed to better understand this complexity.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?