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Recombinant Human Erythropoietin Improves Neurological Outcomes in Very Preterm Infants

Journal article
Authors J. Song
H. Q. Sun
F. L. Xu
W. Q. Kang
L. Gao
J. J. Guo
Y. H. Zhang
L. Xia
Xiaoyang Wang
Changlian Zhu
Published in Annals of Neurology
Volume 80
Issue 1
Pages 24-34
ISSN 0364-5134
Publication year 2016
Published at Institute of Neuroscience and Physiology
Pages 24-34
Language en
Keywords birth-weight infants, high-dose erythropoietin, hypoxia-ischemia, white-matter, brain-injury, retinopathy, neuroprotection, safety, trial, born, Neurosciences & Neurology
Subject categories Neurosciences


Objective: To evaluate the efficacy and safety of repeated low-dose human recombinant erythropoietin (rhEPO) in the improvement of neurological outcomes in very preterm infants. Methods: A total of 800 infants of <= 32-week gestational age who had been in an intensive care unit within 72 hours after birth were included in the trial between January 2009 and June 2013. Preterm infants were randomly assigned to receive rhEPO (500IU/kg; n=366) or placebo (n=377) intravenously within 72 hours after birth and then once every other day for 2 weeks. The primary outcome was death or moderate to severe neurological disability assessed at 18 months of corrected age. Results: Death and moderate/severe neurological disability occurred in 91 of 338 very preterm infants (26.9%) in the placebo group and in 43 of 330 very preterm infants (13.0%) in the rhEPO treatment group (relative risk [RR]=0.40, 95% confidence interval [CI]=0.27-0.59, p < 0.001) at 18 months of corrected age. The rate of moderate/severe neurological disability in the rhEPO group (22 of 309, 7.1%) was significantly lower compared to the placebo group (57 of 304, 18.8%; RR=0.32, 95% CI=0.19-0.55, p < 0.001), and no excess adverse events were observed. Interpretation: Repeated low-dose rhEPO treatment reduced the risk of long-term neurological disability in very preterm infants with no obvious adverse effects.

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