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Natural history of 107 cases of Fetal Aortic Stenosis from a European multicenter retrospective study.

Journal article
Authors Helena Gardiner
Alexander Kovacevic
Gerald Tulzer
Taisto Sarkola
Ulrike Herberg
Joanna Dangel
Annika Öhman
Joachim Bartrons
Julene Carvalho
Hana Jicinska
Vlasta Fesslova
Ian Averiss
Mats Mellander
Published in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Volume 48
Issue 3
Pages 373–381
ISSN 1469-0705
Publication year 2016
Published at
Pages 373–381
Language en
Keywords Fetal cardiology
Subject categories Clinical Medicine


Fetal aortic valvuloplasty (FV) aims to prevent fetal aortic valve stenosis progressing into hypoplastic left heart syndrome (HLHS) resulting in a postnatal univentricular (UV) circulation. Despite increasing numbers of FVs performed worldwide, the natural history of the disease in fetal life remains poorly defined. The primary aim of this study was to describe the natural history of fetal aortic stenosis and, secondarily, to test previously published criteria designed to identify cases of evolving HLHS with the potential for a biventricular (BV) outcome following FV.

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