Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM
| Authors |
Johnny Ludvigsson Annelie Carlsson Ahmed Deli Gun Forsander Sten-A Ivarsson Ingrid Kockum Bengt Lindblad Claude Marcus Ake Lernmark Ulf Samuelsson |
|---|---|
| Published in | Diabetes research and clinical practice |
| Volume | 100 |
| Issue | 2 |
| Pages | 203–209 |
| ISSN | 1872-8227 |
| Publication year | 2013 |
| Published at | |
| Pages | 203–209 |
| Language | en |
| Keywords | C-peptide; Natural course; Type 1 diabetes; Children; BMI; Intervention trials |
| Subject categories | Pediatrics |
AIMS/HYPOTHESIS: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. METHODS: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. RESULTS: Younger children lost more C-peptide (p<0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p<0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p<0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p<0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p<0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. CONCLUSIONS/INTERPRETATION: Even in a restricted geographical area and narrow age range (<18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials.
© UNIVERSITY OF GOTHENBURG • Sweden • Box 100 • SE-405 30 Gothenburg
Phone: +46 31 786 0000 • Contact • Organisation number: 202100-3153
About the website
Facebook
Twitter
Instagram
Youtube
Weibo