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Titanium dioxide nanotubes enhance bone bonding in vivo.

Journal article
Authors LM Bjursten
Lars Rasmusson
Seunghan Oh
Garrett C Smith
Karla S Brammer
Sungho Jin
Published in Journal of biomedical materials research. Part A
Volume 92
Issue 3
Pages 1218-24
ISSN 1552-4965
Publication year 2010
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 1218-24
Language en
Keywords Animals, Bone and Bones, Microscopy, Electron, Scanning, Nanotubes, Rabbits, Titanium
Subject categories Biomaterials


Implant topography is critical to the clinical success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surfaces: titanium dioxide (TiO(2)) nanotubes and TiO(2) gritblasted surfaces. In previous in vitro studies, the topography of the TiO(2) nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO(2) nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO(2) gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength.

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