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Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia.

Journal article
Authors Olle Bergman
Lars Westberg
Lars-Göran Nilsson
Rolf Adolfsson
Elias Eriksson
Published in Progress in neuro-psychopharmacology & biological psychiatry
Volume 34
Issue 6
Pages 1094-7
ISSN 1878-4216
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 1094-7
Language en
Keywords Alleles, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Homeodomain Proteins, genetics, Humans, Polymorphism, Single Nucleotide, Schizophrenia, genetics, Transcription Factors, genetics
Subject categories Pharmacology and Toxicology


The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented.

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