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Slowed reaction time in HIV-1-infected patients without AIDS

Journal article
Authors Åsa Mellgren
Gunnar Norkrans
Lars Hagberg
O. Dunlop
Rune Wejstål
Magnus Gisslén
Published in Acta Neurol Scand
Volume 102
Issue 3
Pages 169-74
Publication year 2000
Published at Institute of Internal Medicine, Dept of Infectious Diseases
Pages 169-74
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords AIDS Dementia Complex/etiology, Adult, Aged, CD4 Lymphocyte Count, Case-Control Studies, Female, HIV Infections/complications/*psychology/virology, HIV-1/*isolation & purification, Hepatitis C, Chronic/psychology, Humans, Male, Middle Aged, *Psychomotor Performance, *Reaction Time, Statistics, Nonparametric
Subject categories Microbiology in the medical area

Abstract

OBJECTIVES: To investigate if HIV-1-infected patients without acquired immunodeficiency syndrome (AIDS) have cerebral dysfunction as reflected by impaired reaction times compared to patients with chronic hepatitis C. MATERIAL AND METHODS: Forty-one HIV-1-infected patients not fulfilling the AIDS criteria, were tested with three reaction time tests and compared to controls with chronic hepatitis C, matched according to gender and age. RESULTS: HIV-1-infected individuals had, in mean, 5-47 ms longer reaction time than patients with hepatitis C (statistically significant in two of three tests). All but 9 HIV-1-infected individuals had, however, reaction times within the normal range defined by the control group (mean +/- 2 SD). No correlation was found between reaction time and immune status measured as CD4-cell count. CONCLUSION: This study indicates that a subgroup of HIV-1-infected individuals have slower reaction time compatible with cerebral deterioration early in the course of the infection.

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