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Association between a polymorphism of the 5-HT2C receptor and weight loss in teenage girls.

Journal article
Authors Lars Westberg
Jessica Bah Rösman
Maria Råstam
Christopher Gillberg
Elisabet Wentz
Jonas Melke
Monika Hellstrand
Elias Eriksson
Published in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume 26
Issue 6
Pages 789-93
ISSN 0893-133X
Publication year 2002
Published at Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 789-93
Language en
Keywords Adolescent, physiology, Chi-Square Distribution, Feeding Behavior, physiology, Female, Humans, Polymorphism, Genetic, genetics, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, genetics, Weight Loss, genetics
Subject categories Pharmacology and Toxicology


Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p =.0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two groups were separately analyzed, both differed significantly from controls with respect to serine allele frequency. The results support the notion that the studied gene may be involved in the regulation of food intake in young women.

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