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A gene expression fingerprint of mouse stomach ECL cells.

Journal article
Authors Niklas Andersson
Sofia Movérare-Skrtic
Rolf Håkanson
Claes Ohlsson
Published in Biochemical and biophysical research communications
Volume 332
Issue 2
Pages 404-10
ISSN 0006-291X
Publication year 2005
Published at Institute of Internal Medicine, Dept of Medicine
Pages 404-10
Language en
Links dx.doi.org/10.1016/j.bbrc.2005.05.0...
Keywords Animals, Cells, Cultured, Enteroendocrine Cells, metabolism, Female, Gastric Mucosa, metabolism, Gastrins, metabolism, Mice, Mice, Inbred C57BL, Omeprazole, Peptide Hormones, metabolism, Peptide Mapping, methods, Proteome, metabolism, Stomach, metabolism, Stomach Diseases, chemically induced, metabolism, Tissue Distribution
Subject categories Medical and Health Sciences

Abstract

Many of the endocrine cells in the stomach are poorly characterized with respect to physiological significance. In some cases, the anticipated hormone has not yet been identified. Global gene expression analysis of mouse stomach was performed in an attempt to identify the ECL-cell peptide/protein. Specific functional activation (omeprazole-induced hypergastrinaemia) was used as a tool to generate a gene expression fingerprint of the ECL cells. The proposed fingerprint includes 14 genes, among them six are known to be expressed by ECL cells (=positive controls), and some novel ones, which are likely to be ECL-cell-related. The known ECL-cell-related genes are those encoding histidine decarboxylase, chromogranin A and B, vesicular monoamine transporter 2, synaptophysin, and the cholecystokinin-B receptor. In addition, the fingerprint included five genes, which might be involved in the process of secretion and three ESTs with unknown function. Interestingly, parathyroid hormone-like hormone (Pthlh) was identified as a candidate ECL-cell peptide hormone.

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