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Asperger syndrome: familial and pre- and perinatal factors.

Journal article
Authors Christopher Gillberg
Mats Cederlund
Published in Journal of Autism and Developmental Disorders
Volume 35
Issue 2
Pages 159-166
ISSN 0162-3257
Publication year 2005
Published at Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Pages 159-166
Language en
Links 10.1007/s10803-005-1993-2
Keywords Adolescent, Asperger Syndrome, Diagnosis, Etiology, Genetics, Child of Impaired Parents, Statistics & numerical data, Chromosome Aberrations, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Medical Records, Perinatology, Pregnancy, Pregnancy Complications, Wechsler Scales
Subject categories Child and adolescent psychiatry


OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.

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