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The IL12B gene does not confer susceptibility to coeliac disease.

Journal article
Authors A S Louka
Åsa Torinsson Naluai
S D'Alfonso
Henry Ascher
I Coto
J Ek
M Giordano
Audur Gudjonsdottir
M Mellai
P Momigliano-Richiardi
S Percopo
L Samuelsson
Jan Wahlström
L Greco
L M Sollid
Published in Tissue antigens
Volume 59
Issue 1
Pages 70-2
ISSN 0001-2815
Publication year 2002
Published at Institute for the Health of Women and Children
Institute for the Health of Women and Children, Dept of Paediatrics
Pages 70-2
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Alleles, Celiac Disease, genetics, pathology, Genetic Predisposition to Disease, HLA-DQ Antigens, genetics, Humans, Interleukin-12, genetics, Interleukin-12 Subunit p40, Intestines, pathology, Italy, Polymorphism, Genetic, Scandinavia
Subject categories Dermatology and Venereal Diseases

Abstract

Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.

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