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Helicobacter pylori adhesion to carbohydrates.

Journal article
Authors Marina Aspholm
Awdhesh Kalia
Stefan Ruhl
Staffan Schedin
Anna Arnqvist
Sara K. Lindén
Rolf Sjöström
Markus Gerhard
Cristina Semino-Mora
Andre Dubois
Magnus Unemo
Dan Danielsson
Susann Teneberg
Woo-Kon Lee
Douglas E Berg
Thomas Borén
Published in Methods in enzymology
Volume 417
Pages 293-339
ISSN 0076-6879
Publication year 2006
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 293-339
Language en
Links dx.doi.org/10.1016/S0076-6879(06)17...
Keywords Bacterial Adhesion, physiology, Carbohydrate Metabolism, Helicobacter pylori, physiology, Humans
Subject categories Medical and Health Sciences

Abstract

Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.

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