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Further insights into the role of angiotensin II in kidney development

Journal article
Authors Daina Lasaitiene
Yun Chen
M. A. Adams
Peter Friberg
Published in Clin Physiol Funct Imaging
Volume 26
Issue 4
Pages 197-204
ISSN 1475-0961 (Print)
Publication year 2006
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 197-204
Language en
Keywords Angiotensin II/*physiology, Animals, Blood Pressure/physiology, Kidney/*embryology/ultrastructure, Models, Biological, Organogenesis, Receptors, Angiotensin/physiology, Renin-Angiotensin System/physiology
Subject categories Medical and Health Sciences


Over the past decade, compelling studies have highlighted the fundamental role of the renin-angiotensin system (RAS) in renal development and long-term control of renal function and arterial pressure. The present review provides an update of the understanding of how the RAS controls nephrogenesis and nephrovascular development. In addition, the investigations linking the perinatal development of RAS inhibition-induced renal dysmorphology and establishment of adult blood pressure are discussed.

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