To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Serum phospholipid fatty … - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents

Journal article
Authors Martin Karlsson
Staffan Mårild
John Brandberg
Lars Lönn
Peter Friberg
Birgitta Strandvik
Published in Obesity (Silver Spring)
Volume 14
Issue 11
Pages 1931-9
ISSN 1930-7381 (Print)
Publication year 2006
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Clinical Sciences
Pages 1931-9
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Abdominal Fat/*metabolism, Adolescent, Analysis of Variance, Biological Markers, Case-Control Studies, Child, Fatty Acids/*analysis/blood, Fatty Acids, Omega-3/analysis/blood, Female, Humans, Magnetic Resonance Imaging, Male, Obesity/blood/*metabolism, Phospholipids/blood/chemistry, Sex Factors
Subject categories Medical and Health Sciences

Abstract

OBJECTIVE: Fatty acid (FA) composition has a role in adipogenesis. The objective was to study serum phospholipid (PL) FAs in adolescents and their relation to abdominal adipose tissue (AT) compartments and metabolic markers. RESEARCH METHODS AND PROCEDURES: Abdominal AT was measured by magnetic resonance imaging and FA pattern was determined in serum PL of 10 obese adolescents (5 females), median age 12.0 years (range, 10.4 to 16.4) and BMI 30.7 (26.8 to 40.4), and 15 lean control subjects (9 females), median age 12.6 years (range, 11.3 to 15.4), and BMI 19.5 (17.1 to 23.4). RESULTS: Obese adolescents had relatively higher levels of saturated FA (SFA) and nervonic acid compared with controls. Serum PL concentration of n-3 polyunsaturated fatty acids (PUFA) was lower in the obese vs. lean females (p = 0.01), including docosahexaenoic acid (DHA) (p = 0.01). The ratios of arachidonic acid to DHA and total n-6/n-3 FA were increased in obese children (p = 0.02 and 0.01, respectively). n-3 PUFAs were inversely correlated to all subcutaneous AT compartments except visceral AT. The homeostasis model assessment index of beta-cell function related inversely to DHA concentration (p = 0.03). All changes were more marked in the females. DISCUSSION: Serum FA pattern in obese adolescents differed significantly from that in age-matched lean controls, reflecting a decrease in n-3 PUFA, especially DHA, and an increase in SFA. The subcutaneous AT, but not visceral AT, correlated to the changes in PUFA and SFA, suggesting an abnormal essential FA metabolism in obese adolescents.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?