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Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.

Journal article
Authors Jenny Nyberg
Michelle F Anderson
Björn Meister
Ann-Marie Alborn
Anna-Karin Ström
Anke Brederlau
Ann-Christin Illerskog-Lindström
Ola Nilsson
Timothy J Kieffer
Max Albert Hietala
Anne Ricksten
Peter S Eriksson
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume 25
Issue 7
Pages 1816-25
ISSN 1529-2401
Publication year 2005
Published at Institute of Laboratory Medicine, Dept of Pathology
Institute of Clinical Neurosciences
Institute of Anatomy and Cell Biology
Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
Pages 1816-25
Language en
Keywords Animals, Cell Division, drug effects, Dentate Gyrus, cytology, metabolism, Female, Gastric Inhibitory Polypeptide, biosynthesis, genetics, pharmacology, physiology, Gene Expression Profiling, Hypertension, genetics, metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, cytology, drug effects, Oligonucleotide Array Sequence Analysis, Rats, Rats, Inbred SHR, Rats, Sprague-Dawley, Receptors, Gastrointestinal Hormone, deficiency, genetics, physiology, Stem Cells, cytology
Subject categories Medical and Health Sciences


The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis within the adult brain. The molecular events controlling adult cell genesis in the hippocampus essentially remain unknown. It has been reported previously that adult male and female rats from the strains Sprague Dawley (SD) and spontaneously hypertensive (SHR) have a marked difference in proliferation rates of cells in the hippocampal DG. To exploit this natural variability and identify potential regulators of cell genesis in the hippocampus, hippocampal gene expression from male SHR as well as male and female SD rats was analyzed using a cDNA array strategy. Hippocampal expression of the gene-encoding glucose-dependent insulinotropic polypeptide (GIP) varied strongly in parallel with cell-proliferation rates in the adult rat DG. Moreover, robust GIP immunoreactivity could be detected in the DG. The GIP receptor is expressed by cultured adult hippocampal progenitors and throughout the granule cell layer of the DG, including progenitor cells. Thus, these cells have the ability to respond to GIP. Indeed, exogenously delivered GIP induced proliferation of adult-derived hippocampal progenitors in vivo as well as in vitro, and adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal DG compared with wild-type mice. This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation.

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