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Identification of genes predominantly expressed in human macrophages

Journal article
Authors Per Anders Svensson
Daniel Hägg
Margareta Jernås
Mikael C. O. Englund
Lillemor Mattsson Hultén
Bertil Ohlsson
Johannes Hulthe
Olov Wiklund
Björn Carlsson
Björn Fagerberg
Lena M S Carlsson
Published in Atherosclerosis
Volume 177
Issue 2
Pages 287-90
Publication year 2004
Published at Wallenberg Laboratory
Cardiovascular Institute
Institute of Internal Medicine, Dept of Medicine
Institute of Internal Medicine
Institute of Internal Medicine, Dept of Body Composition and Metabolism
Pages 287-90
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords DNA-Binding Proteins, Humans, Interleukin 1 Receptor Antagonist Protein, Macrophages/chemistry/*physiology, Oligonucleotide Array Sequence Analysis, Receptors, Cytoplasmic and Nuclear/*genetics, Sialoglycoproteins/*genetics, Tissue Distribution
Subject categories Medical and Health Sciences

Abstract

Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.

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