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Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice

Journal article
Authors Viktor Johanson
Yvonne Arvidsson
Lars Kölby
Peter Bernhardt
Christina Swärd
Ola Nilsson
Håkan Ahlman
Published in Neuroendocrinology
Volume 82
Issue 3-4
Pages 171-6
ISSN 0028-3835 (Print)
Publication year 2005
Published at Institute of Selected Clinical Sciences, Department of Radiation Physics
Institute of Laboratory Medicine, Dept of Pathology
Institute of Surgical Sciences, Department of Surgery
Pages 171-6
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Animals, Antineoplastic Agents/*therapeutic use, Cell Line, Tumor, Cyanides/*therapeutic use, Female, Guanidines/*therapeutic use, Humans, Mice, Mice, Nude, Neoplasm Transplantation, Neuroendocrine Tumors/*drug therapy, Xenograft Model Antitumor Assays
Subject categories Medical and Health Sciences

Abstract

CHS 828, a cyanoguanidine with potent experimental antitumoural activity, inhibits activation of nuclear factor-kappaB. In the present study, marked antitumoural activity of peroral CHS 828 was shown against three different human neuroendocrine tumours, midgut carcinoid (GOT1), pancreatic carcinoid (BON), and medullary thyroid carcinoma (GOT2), transplanted in nude mice. Our results indicate that CHS 828 can be a candidate drug for treatment of neuroendocrine tumours.

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