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The role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis.

Journal article
Authors Majd Mohammad
Zhicheng Hu
Abukar Ali
Pradeep Kumar Kopparapu
Manli Na
Anders Jarneborn
Mariana do Nascimento Stroparo
Minh-Thu Nguyen
Anna Karlsson
Friedrich Götz
Rille Pullerits
Tao Jin
Published in Scientific reports
Volume 10
Pages 7936
ISSN 2045-2322
Publication year 2020
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 7936
Language en
Subject categories Infectious Medicine, Microbiology in the medical area


Permanent joint dysfunction is a devastating complication in patients with septic arthritis. Staphylococcus aureus (S. aureus) lipoproteins (Lpp), the predominant ligands for TLR2, are known to be arthritogenic and induce bone destruction when introduced directly into the joint. Here, we aim to investigate the importance of S. aureus Lpp and TLR2 in a hematogenous septic arthritis model, which is the most common route of infection in humans. C57BL/6 wild-type and TLR2 deficient mice were intravenously inoculated with S. aureus Newman parental strain or its lipoprotein-deficient Δlgt mutant strain. The clinical course of septic arthritis, radiological changes, and serum levels of cytokines and chemokines, were assessed. Newman strain induced more severe and frequent clinical septic polyarthritis compared to its Δlgt mutant in TLR2 deficient mice, but not in wild-type controls. Bone destruction, however, did not differ between groups. Lpp expression was associated with higher mortality, weight loss as well as impaired bacterial clearance in mouse kidneys independent of TLR2. Furthermore, Lpp expression induced increased systemic pro-inflammatory cytokine and neutrophil chemokine release. Staphylococcal Lpp are potent virulence factors in S. aureus systemic infection independent of host TLR2 signalling. However, they have a limited impact on bone erosion in hematogenous staphylococcal septic arthritis.

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