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Isolation and Characterization of MAIT Cells from Tumor Tissues

Chapter in book
Authors William Rodin
Patrik Sundström
Marianne Quiding-Järbrink
Published in MAIT Cells. Methods and Protocols. Helen KaipeIsabelle Magalhaes (red.)
Pages 39-53
ISBN 978-1-0716-0206-5
Publisher Springer
Publication year 2020
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 39-53
Language en
Links dx.doi.org/10.1007/978-1-0716-0207-...
Subject categories Immunology in the medical area

Abstract

Mucosal-associated invariant T (MAIT) cell infiltration has been demonstrated in colorectal and hepatocellular carcinoma, and their ability to produce Th1- and Th17-associated cytokines, as well as their cytotoxic function, suggests that MAIT cells may have important functions in both reducing and promoting protective tumor immunity. Here, we describe enzymatic methods to isolate intraepithelial and lamina propria lymphocyte single cell suspensions from colon tissue and tumors containing viable MAIT cells, which can be used for further purification, flow cytometry analysis, or culture.

Page Manager: Webmaster|Last update: 9/11/2012
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