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Free and hydrogel encapsulated exosome-based therapies in regenerative medicine.

Journal article
Authors Ali Akbari
Nassrollah Jabbari
Roholah Sharifi
Mahdi Ahmadi
Ali Vahhabi
Seyyed Javad Seyedzadeh
Muhammad Nawaz
Sławomir Szafert
Monireh Mahmoodi
Esmaiel Jabbari
Rahim Asghari
Jafar Rezaie
Published in Life sciences
Volume 249
ISSN 1879-0631
Publication year 2020
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Language en
Links dx.doi.org/10.1016/j.lfs.2020.11744...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Exosomes, Extracellular vesicles,
Subject categories Medical Biotechnology, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Abstract

Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are extracellular vehicles (EVs) that play important roles in cell-cell communication through various processes such as stress response, senescence, angiogenesis, and cell differentiation. Success in the field of regenerative medicine sparked exploration of the potential use of exosomes as key therapeutic effectors of MSCs to promote tissue regeneration. Various approaches including direct injection, intravenous injection, intraperitoneal injection, oral administration, and hydrogel-based encapsulation have been exploited to deliver exosomes to target tissues in different disease models. Despite significant advances in exosome therapy, it is unclear which approach is more effective for administering exosomes. Herein, we critically review the emerging progress in the applications of exosomes in the form of free or association with hydrogels as therapeutic agents for applications in regenerative medicine.

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