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Understanding Long Noncoding RNA and Chromatin Interactions: What We Know So Far

Journal article
Authors Kankadeb Mishra
Chandrasekhar Kanduri
Published in Non-Coding Rna
Volume 5
Issue 4
Pages 28
Publication year 2019
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 28
Language en
Links dx.doi.org/10.3390/ncrna5040054
Keywords lncrna, chromatin, chromatin RNA, long noncoding RNA, gene regulation, RNA-chromatin interactions, repeat-containing rna, r-loop formation, antisense transcription, wide, identification, active chromatin, binding protein, enhancer rnas, circular rnas, x-chromosome, maps reveal, Biochemistry & Molecular Biology, Genetics & Heredity
Subject categories Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Abstract

With the evolution of technologies that deal with global detection of RNAs to probing of lncRNA-chromatin interactions and lncRNA-chromatin structure regulation, we have been updated with a comprehensive repertoire of chromatin interacting lncRNAs, their genome-wide chromatin binding regions and mode of action. Evidence from these new technologies emphasize that chromatin targeting of lncRNAs is a prominent mechanism and that these chromatin targeted lncRNAs exert their functionality by fine tuning chromatin architecture resulting in an altered transcriptional readout. Currently, there are no unifying principles that define chromatin association of lncRNAs, however, evidence from a few chromatin-associated lncRNAs show presence of a short common sequence for chromatin targeting. In this article, we review how technological advancements contributed in characterizing chromatin associated lncRNAs, and discuss the potential mechanisms by which chromatin associated lncRNAs execute their functions.

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