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Repeated lumbar punctures within 3 days may affect CSF biomarker levels.

Journal article
Authors Martin Olsson
Johan Ärlig
Jan A Hedner
Kaj Blennow
Henrik Zetterberg
Published in Fluids and barriers of the CNS
Volume 16
Issue 1
Pages 37
ISSN 2045-8118
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 37
Language en
Links dx.doi.org/10.1186/s12987-019-0157-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer's disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but without sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.

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