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Plasma neurofilament light in progressive multiple sclerosis.

Editorial letter
Authors Henrik Zetterberg
Published in Acta neurologica Scandinavica
ISSN 1600-0404
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Language en
Links dx.doi.org/10.1111/ane.13184
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

Neurofilaments (Nfs) are a family of neuronal intermediate filaments involved in the growth and stability of axons, and, through incorporation into different supramolecular assemblies, also in synaptic organization and function in the central nervous system. Pioneering work by Lars Rosengren and colleagues in the late 1980s led to the establishment of an enzyme-linked immunosorbent assay (ELISA) based on polyclonal antisera that allowed for the reliable quantification of the neurofilament light (NfL) subunit in cerebrospinal fluid (CSF).

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