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Immunotherapy with HDC/IL-2 may be clinically efficacious in acute myeloid leukemia of normal karyotype

Journal article
Authors Malin S. Nilsson
Alexander Hallner
Mats Brune
Staffan Nilsson
Fredrik Bergh Thorén
Anna Martner
Kristoffer Hellstrand
Published in Human Vaccines & Immunotherapeutics
ISSN 2164-5515
Publication year 2019
Published at Department of Mathematical Sciences
Sahlgrenska Cancer Center
Institute of Medicine
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Biomedicine, Department of Infectious Medicine
Language en
Links dx.doi.org/10.1080/21645515.2019.16...
Keywords Acute myeloid leukemia, histamine dihydrochloride, IL-2, immunotherapy, relapse prevention, mutations, aml, Biotechnology & Applied Microbiology, Immunology
Subject categories Immunology in the medical area, Hematology, Cancer and Oncology

Abstract

Immunotherapy with histamine dihydrochloride and low-dose interleukin-2 (HDC/IL-2) reduces the risk of relapse in the post-chemotherapy phase of acute myeloid leukemia (AML). Here we report the results of exploratory analyses of the clinical efficacy of HDC/IL-2 in AML with focus on the impact of karyotype aberrations in leukemic cells. Post-hoc analyses of phase III trial data suggested that HDC/IL-2 is primarily beneficial for patients with AML of normal karyotype. These results may be helpful in the selection of patients who are suitable for therapy and in the design of future immunotherapy protocols aiming at further defining the mechanism of relapse prevention by HDC/IL-2.

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