To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A sensitive method detect… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

A sensitive method detecting trace levels of levonorgestrel using LC-HRMS

Journal article
Authors S. Abujrais
M. Olovsson
Martin Ahnoff
A. J. Rasmusson
A. Larsson
T. Åkerfeldt
K. Kultima
Published in Contraception
Volume 100
Issue 3
Pages 247-249
ISSN 0010-7824
Publication year 2019
Published at Department of marine sciences
Pages 247-249
Language en
Keywords High resolution mass spectrometry, Intrauterine device, Liquid chromatography, Lower limit of quantification, Solid phase extraction
Subject categories Biochemistry


Objective: To develop a high resolution mass spectrometry (HRMS) method to quantify levonorgestrel (LNG) in serum. Study design: Levonorgestrel was extracted using solid phase extraction and measured using liquid chromatography (LC) HRMS. Results: Low limit of quantification (LLOQ) was 25 pg/mL and low limit of detection (LLOD) was 12.5 pg/mL. Precision and accuracy bias were <10%. LNG in serum samples from Mirena® users ranged between 37 to 219 pg/mL (n=12). In eight out of 22 patients with suspected intrauterine device (IUD) expulsion LNG was detected (26–1272 pg/mL). Conclusion: A sensitive, fast and simple LC-HRMS method was developed to detect trace levels of LNG. © 2019 Elsevier Inc.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?