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Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest

Journal article
Authors J. Grand
J. Kjaergaard
N. Nielsen
H. Friberg
T. Cronberg
J. Bro-Jeppesen
M. A. Karsdal
H. B. Nielsen
M. Frydland
K. Henriksen
N. Mattsson
Henrik Zetterberg
C. Hassager
Published in Biomarkers
Volume 24
Issue 6
Pages 584-591
ISSN 1354-750X
Publication year 2019
Published at Institute of Neuroscience and Physiology
Pages 584-591
Language en
Links dx.doi.org/10.1080/1354750X.2019.16...
Keywords neurological outcome, out-of-hospital cardiac arrest, prognosis, Serum biomarkers, tau fragments
Subject categories Cardiovascular medicine, Neurology

Abstract

Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1–quartile 3) tau-A (ng/ml) values were 58 (43–71) versus 51 (43–67), 72 (57–84) versus 71 (59–82) and 76 (61–92) versus 75 (64–89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29–50) versus 36 (29–49), 49 (38–58) versus 48 (33–59) and 48 (39–59) versus 48 (36–62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

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