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Organization of DNA in mammalian mitochondria

Journal article
Authors G. É R. Farge
Maria Falkenberg
Published in International Journal of Molecular Sciences
Volume 20
Issue 11
ISSN 1661-6596
Publication year 2019
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Links dx.doi.org/10.3390/ijms20112770
Keywords Mitochondrial DNA, MtDNA compaction, MtDNA maintenance, MtDNA replication, MtDNA transcription
Subject categories Cell and molecular biology

Abstract

As with all organisms that must organize and condense their DNA to fit within the limited volume of a cell or a nucleus, mammalian mitochondrial DNA (mtDNA) is packaged into nucleoprotein structures called nucleoids. In this study, we first introduce the general modes of DNA compaction, especially the role of the nucleoid-associated proteins (NAPs) that structure the bacterial chromosome. We then present the mitochondrial nucleoid and the main factors responsible for packaging of mtDNA: ARS-(autonomously replicating sequence-) binding factor 2 protein (Abf2p) in yeast and mitochondrial transcription factor A (TFAM) in mammals. We summarize the single-molecule manipulation experiments on mtDNA compaction and visualization of mitochondrial nucleoids that have led to our current knowledge on mtDNA compaction. Lastly, we discuss the possible regulatory role of DNA packaging by TFAM in DNA transactions such as mtDNA replication and transcription. © 2019 by the author. Licensee MDPI, Basel, Switzerland.

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