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A 17-marker panel for global genomic instability in breast cancer.

Journal article
Authors Jana Biermann
Szilárd Nemes
Toshima Z Parris
Hanna Engqvist
Elisabeth Werner Rönnerman
Anikó Kovács
Per Karlsson
Khalil Helou
Published in Genomics
ISSN 0888-7543
Publication year 2019
Published at Institute of Clinical Sciences, Department of Oncology
Sahlgrenska Cancer Center
Institute of Biomedicine, Department of Pathology
Language en
Links dx.doi.org/10.1016/j.ygeno.2019.06....
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Biological Sciences, Genetics, Cancer and Oncology

Abstract

Genomic instability is a hallmark of cancer that plays a pivotal role in breast cancer development and evolution. A number of existing prognostic gene expression signatures for breast cancer are based on proliferation-related genes. Here, we identified a 17-marker panel associated with genome stability. A total of 136 primary breast carcinomas were stratified by genome stability. Matched gene expression profiles showed an innate segregation based on genome stability. We identified a 17-marker panel stratifying the training and validation cohorts into high- and low-risk patients. The 17 genes associated with genomic instability strongly impacted clinical outcome in breast cancer. Pathway analyses determined chromosome organisation, cell cycle regulation, and RNA processing as the underlying biological processes, thereby offering options for drug development and treatment tailoring. Our work supports the applicability of the 17-marker panel to improve clinical outcome prediction for breast cancer patients based on a signature accounting for genomic instability.

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