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Urate and risk of Alzheimer's disease and vascular dementia: A population-based study

Journal article
Authors Lieke Scheepers
Lennart T. H. Jacobsson
Silke Kern
Lena Johansson
Mats Dehlin
Ingmar Skoog
Published in Alzheimers & Dementia
Volume 15
Issue 6
Pages 754-763
ISSN 1552-5260
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 754-763
Language en
Keywords Urate, Vascular dementia, Alzheimer's disease, Epidemiology, Oxidative stress, uric-acid, diagnostic-criteria, oxidative stress, serum urate, follow-up, women, prevalence, gout, pathogenesis, gothenburg
Subject categories Neurosciences


Introduction: Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia. Methods: In 1968-1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in 1968-1969 and 1992-1994) is associated with risk of late-life dementia. Results: During 44 years of follow-up, a higher sU (per standard deviation of 76.5 mu mol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72-0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66-0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47-0.94). Discussion: Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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