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Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages.

Journal article
Authors Manman Guo
Anetta Härtlova
Marek Gierliński
Alan Prescott
Josep Castellvi
Javier Hernandez Losa
Sine Kragh Petersen
Ulf Alexander Wenzel
Brian D Dill
Christoph H Emmerich
Santiago Ramon Y Cajal
David G Russell
Matthias Trost
Published in The EMBO journal
Volume 38
Issue 11
ISSN 1460-2075
Publication year 2019
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Wallenberg Centre for Molecular and Translational Medicine
Language en
Links dx.doi.org/10.15252/embj.2018100299
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Immunology in the medical area, Cell and Molecular Biology

Abstract

Alternatively activated M2 macrophages play an important role in maintenance of tissue homeostasis by scavenging dead cells, cell debris and lipoprotein aggregates via phagocytosis. Using proteomics, we investigated how alternative activation, driven by IL-4, modulated the phagosomal proteome to control macrophage function. Our data indicate that alternative activation enhances homeostatic functions such as proteolysis, lipolysis and nutrient transport. Intriguingly, we identified the enhanced recruitment of the TAK1/MKK7/JNK signalling complex to phagosomes of IL-4-activated macrophages. The recruitment of this signalling complex was mediated through K63 polyubiquitylation of the macrophage scavenger receptor 1 (MSR1). Triggering of MSR1 in IL-4-activated macrophages leads to enhanced JNK activation, thereby promoting a phenotypic switch from an anti-inflammatory to a pro-inflammatory state, which was abolished upon MSR1 deletion or JNK inhibition. Moreover, MSR1 K63 polyubiquitylation correlated with the activation of JNK signalling in ovarian cancer tissue from human patients, suggesting that it may be relevant for macrophage phenotypic shift in vivo Altogether, we identified that MSR1 signals through JNK via K63 polyubiquitylation and provides evidence for the receptor's involvement in macrophage polarization.

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