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Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database.

Journal article
Authors Canan Gündüz
Ozen K Basoglu
Jan A Hedner
Ding Zou
Maria R Bonsignore
Holger Hein
Richard Staats
Athanasia Pataka
Ferran Barbe
Pavel Sliwinski
Brian D Kent
Jean Lois Pepin
Ludger Grote
Published in Respirology (Carlton, Vic.)
Volume 23
Issue 12
Pages 1180-1189
ISSN 1440-1843
Publication year 2018
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 1180-1189
Language en
Links dx.doi.org/10.1111/resp.13372
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Respiratory Medicine and Allergy

Abstract

Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort.The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2 , mean apnoea-hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis.There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I-IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe.OSA severity was independently associated with cholesterol and TG concentrations.

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