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Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes.

Journal article
Authors Petr Janku
Marian Kacerovsky
Barbora Zednikova
Ctirad Andrys
Martina Kolackova
Marcela Drahosova
Lenka Pliskova
Helena Zemlickova
Romana Gerychova
Ondrej Simetka
Petr Matlak
Bo Jacobsson
Ivana Musilova
Published in Fetal diagnosis and therapy
Pages 1-9
ISSN 1421-9964
Publication year 2019
Published at Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 1-9
Language en
Links dx.doi.org/10.1159/000499482
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Obstetrics and gynaecology, Obstetrics and women's diseases, Obstetrics, Gynecology and Reproductive Medicine, Clinical Medicine

Abstract

To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI).A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay.PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM.PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.

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