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GATA3 as a putative marker of breast cancer metastasis-A retrospective immunohistochemical study.

Journal article
Authors Shahin De Lara
Toshima Z Parris
Elisabeth Werner Rönnerman
Khalil Helou
Anikó Kovács
Published in The breast journal
Volume 24
Issue 2
Pages 184-188
ISSN 1524-4741
Publication year 2018
Published at Institute of Clinical Sciences, Department of Oncology
Sahlgrenska Cancer Center
Institute of Clinical Sciences
Pages 184-188
Language en
Keywords Adult, Aged, Biomarkers, Tumor, metabolism, Breast Neoplasms, diagnosis, metabolism, pathology, Female, GATA3 Transcription Factor, metabolism, Humans, Mammaglobin A, metabolism, Middle Aged, Neoplasm Metastasis, Retrospective Studies
Subject categories Pathology


Diagnostic verification of breast cancer metastasis with histopathology and imaging analysis is essential to determine tumor staging. The aim of this study was to validate the utility of GATA3 immunohistochemistry as a diagnostic marker for breast cancer metastases and metastases of unknown primary origin. Retrospective immunohistochemical analysis of GATA3 expression in 164 breast cancer metastases diagnosed between 2004 and 2014 showed a striking difference between mammaglobin and GATA3 expression (51.2% vs 94% positivity). These findings highlight GATA3 as a more reliable and sensitive diagnostic marker for breast cancer metastases and possibly metastatic tumors of unknown origin than mammaglobin.

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