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Imaging of vitamin D in psoriatic skin using time-of-flight secondary ion mass spectrometry (ToF-SIMS): A pilot case study.

Journal article
Authors Maria Siekkeri Vandikas
Evelina Hellström
Per Malmberg
Amra Osmancevic
Published in The Journal of steroid biochemistry and molecular biology
Volume 189
Pages 154-160
ISSN 1879-1220
Publication year 2019
Published at Institute of Clinical Sciences, Department of Dermatology and Venereology
Pages 154-160
Language en
Links dx.doi.org/10.1016/j.jsbmb.2019.02....
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords vitamin D
Subject categories Dermatology and Venereal Diseases

Abstract

Recently it has been recognized that there is a need of investigating in detail the vitamin D synthesis and metabolism directly in the skin with respect to its possible autocrine and paracrine actions. The potential effects the active metabolite of vitamin D exerts in pathological skin conditions like psoriasis needs to be clarified. Under ultraviolet B (UVB) irradiation skin can autonomously synthesize, activate and degrade vitamin D. In this pilot case study, we used for the first time Time-of-flight secondary ion mass spectrometry (ToF-SIMS) in the analysis of skin biopsies from a patient with psoriasis before and after UVB phototherapy. We were able to visualize vitamin D3 and its metabolites in the skin and subcutaneous tissue. At the same time information about their localization at subcellular level and morphology of the skin was received. This study proves that ToF-SIMS is a promising powerful tool to be used when investigating vitamin D´s role in dermatological diseases through skin biopsies.

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