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Ribavirin: Pharmacology, multiple modes of action and possible future perspectives

Review article
Authors Kristina Nyström
Jesper Waldenström
Ka-Wei Tang
Martin Lagging
Published in Future Virology
Volume 14
Pages 153-160
ISSN 1746-0794
Publication year 2019
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 153-160
Language en
Keywords GTP, IMPDH, inosine monophosphate dehydrogenase, inosine triphosphate pyrophosphatase, ITPase, mechanism of action, mode of action, mutagenesis, ribavirin
Subject categories Infectious Medicine


© 2019 2019 Martin Lagging. Ribavirin is a unique guanosine analog with broad-spectrum activity against many RNA and DNA viruses. In addition to its mutational properties, ribavirin exerts extensive perturbation of cellular and viral gene expression. Furthermore, recent advances indicate that the impact of ribavirin on divergent cellular and viral pathways may be concentration dependent. This review aims at providing an overview of the pharmacology and multiple modes of action of ribavirin as well as pointing to possible novel future uses.

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