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Combined Amperometry and Electrochemical Cytometry Reveal Differential Effects of Cocaine and Methylphenidate on Exocytosis and the Fraction of Chemical Release

Journal article
Authors Wanying Zhu
Chaoyi Gu
Johan Dunevall
Lin Ren
Xuemin Zhou
Andrew G Ewing
Published in Angewandte Chemie - International Edition
Volume 58
Pages 4238-4242
ISSN 1433-7851
Publication year 2019
Published at Department of Chemistry and Molecular Biology
Pages 4238-4242
Language en
Links doi.org/10.1002/anie.201813717
Keywords catecholamines, cocaine, exocytosis, methylphenidate, vesicles
Subject categories Electrochemistry, Analytical Chemistry

Abstract

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Amperometry with nanotip electrodes has been applied to show cocaine and methylphenidate not only trigger declines in vesicle content and exocytotic catecholamine release in a model cell line but also differentially change the fraction of transmitter released from each individual vesicle. In addition, cocaine accelerates exocytotic release dynamics while they remain unchanged after methylphenidate treatment. The parameters from pre-spike feet for the two drugs are also in opposition, suggesting this aspect of release is affected differentially. As cocaine and methylphenidate are psychostimulants with similar pharmacologic action but have opposite effects on cognition, these results might provide a missing link between the regulation of exocytosis and vesicles and the effect of this regulation on cognition, learning, and memory. A speculative chemical mechanism of the effect of these drugs on vesicle content and exocytosis is presented.

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