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LncRNAs join hands together to regulate neuroblastoma progression.

Review article
Authors Tanmoy Mondal
Chandrasekhar Kanduri
Published in Molecular & cellular oncology
Volume 6
Issue 1
ISSN 2372-3556
Publication year 2019
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Links dx.doi.org/10.1080/23723556.2018.15...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Long noncoding RNA, Cancer, Neuroblastoma
Subject categories Medical Biotechnology, Basic Medicine

Abstract

Trait associated single nucleotide polymorphisms often overlap with noncoding transcripts but their contribution to disease phenotype is poorly investigated. Our study on neuroblastoma risk associated 6p22.3 locus derived long noncoding RNAs (lncRNAs) demonstrates that functional co-operation between sense-antisense CASC15 and NBAT1 lncRNAs control neuroblastoma progression via regulating SOX9-CHD7-USP36 regulatory axis.

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